Harnessing a Physiologic Mechanism for siRNA Delivery With Mimetic Lipoprotein Particles
نویسندگان
چکیده
منابع مشابه
Harnessing a Physiologic Mechanism for siRNA Delivery With Mimetic Lipoprotein Particles
Therapeutics based on RNA interference (RNAi) have emerged as a potential new class of drugs for treating human disease by silencing the target messenger RNA (mRNA), thereby reducing levels of the corresponding pathogenic protein. The major challenge for RNAi therapeutics is the development of safe delivery vehicles for small interfering RNAs (siRNAs). We previously showed that cholesterol-conj...
متن کاملMulticompartmental particles for combined imaging and siRNA delivery.
The controlled delivery of genetic material, such as genes, plasmids, or siRNA, holds great promise for the therapy of a number of debilitating diseases. [ 1–3 ] While the fundamental concept of permanent or temporary genetic manipulation has been widely embraced by the scientifi c community, severe concerns remain about the safe and effi cient transfer of the genetic material into human cells,...
متن کاملDendrimers for siRNA Delivery
Since the discovery of the "starburst polymer", later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups. In recent years, dendrimers have been studied extensively...
متن کاملGlucan particles for selective delivery of siRNA to phagocytic cells in mice.
Phagocytic macrophages and dendritic cells are desirable targets for potential RNAi (RNA interference) therapeutics because they often mediate pathogenic inflammation and autoimmune responses. We recently engineered a complex 5 component glucan-based encapsulation system for siRNA (small interfering RNA) delivery to phagocytes. In experiments designed to simplify this original formulation, we d...
متن کاملsiRNA delivery and targeting.
RNA interference (RNAi) is one of the most dramatic findings over the past decade, and the number of publications related to RNAi increased exponentially from 5 in 1998 to more than 2400 in 2008. Generally, RNAi can be achieved by three strategies: chemical synthesized small interfering RNA (siRNA), long double-stranded RNA (dsRNA), and DNA-based (plasmid or viral vector) short hairpin RNA (shR...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2012
ISSN: 1525-0016
DOI: 10.1038/mt.2012.33